Current Issue : July-September Volume : 2016 Issue Number : 3 Articles : 4 Articles
Despite phenomenal advances in the injectable, inhalable, transdermal, nasal and other delivery systems, the oral route is still considered the most preferable for both patients and industry. Being natural, noninvasive and safe method of drug delivery, oral delivery is, always, associated with high degree of patient compliance. On the other hand, oral delivery systems are able to accommodate various physicochemical properties of drugs, do not require strict sterile conditions and therefore less expensive to manufacture. Thus, even small improvements in oral drug delivery technology can make significant difference in enhancing patient compliance and drug delivery fields in general. Over the past decades, several novel technologies for oral delivery have been developed, examples include; oral rapid disintegrating (dissolving) tablets, mucoadhesive buccal dosage forms, site specific drug delivery and novel controlled release dosage forms. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for MDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area....
In solving the low bioavailability of poor water soluble drugs self micro emulsifying drug delivery system (SMEDDS) forms the main technique. This system can enable the hydrophobic drugs to dissolve easily in the system by formulating them in to unit dosage forms mainly for per oral administration. When this system is released in the gastrointestinal tract (lumen) it disperses resulting in the fine emulsion with particle size ranging from micro to nano. The pseudo-ternary phase diagrams are drawn to identify the micro emulsion region. The SMEDDS are evaluated for physico-chemical properties, drug release, diffusion and permeation and zeta potential....
The aim of this study was to design and characterize press coated tablet of carvedilol for colon targeted drug delivery. The drug delivery system was based on the gastrointestinal transit time concept, assuming colon arrival time to be 5 h. To improve the solubility and dissolution rate of carvedilol inclusion complex was prepared by kneading method. Core tablet was prepared by direct compression using superdisintegrants sodium starch glycolate and crosscarmellose sodium. The core tablet was compression coated with different quantities of coating material containing different polymers. A 32 full factorial design was used for optimization of barrier layer. The ratio of hydroxypropylmethylcellulose K100M: Ethyl cellulose (X1) and coat weight (X2) were selected as independent variables. The lag time and percentage drug release at 12 h (Q12) were selected as dependent variables. Tablets were evaluated for hardness, friability, weight variation, drug content, in-vitro drug release and stability study. Comparative dissolution profiles of all the batches indicate drug release from tablet was inversely proportional to coat weight. The kinetics release of optimize batch P5 was best explained by zero order and Korsmeyerââ?¬â??Peppas kinetic model. The press coated tablets coated with HPMC K100M: EC in 50:50 ratios with 230 mg coat weight were most likely to provide targeted delivery of carvedilol to the colon....
Oral route has always been preferred route for formulation and dominated over other routes of administration. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Thymoquinone is an anticancer, anti-arthritis and anti-inflammatory agent having poor oral solubility. Objective of present study was to increase solubility of thymoquinone with the help of self-micro emulsifying drug delivery system D-optimal mixture design. Solubility of thymoquinone was found in various oils (synthetic and edible) and co-surfactant ratio with saturation increment method, from that pseudoternary phase diagram was prepared for selection of oil, surfactant and co-surfactant ratio. D-optimal mixture design was used to formulate SMEDDS. Formulations were optimized for viscosity, % transmittance, globule size, zeta potential, TEM and pH....
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